SFI Health

Ginkgo and Ginseng (Gingko biloba GK501 & Panax ginseng G115)

Enhance mental alertness and cognitive performance 

In Gincosan®, two specific standardised extracts from the roots of Panax ginseng C.A. Meyer and the leaves of Ginkgo biloba, have been combined to create a unique patented formulation of GK105 (ginkgo) and G115 (ginseng).

Discover more about the G115 and GK105 extracts used by SFI Health, how they work together, and the key studies that support their benefits when used in Gincosan.

Always read the label. Follow the directions for use. Contains lactose. 

Ginkgo biloba and Panax ginseng in history

Ginkgo biloba L. belongs to the family of Ginkgoaceae, and is believed to be the oldest living tree. Extracts and infusions from the leaves of Ginkgo have been used in history for thousands of years.

Panax ginseng is a perennial shrub, native to north-eastern China, Korea and Russia. Panax ginseng was first recorded in Chinese medicine over 2000 years ago, and was already the subject of over 600 published books and papers before the year 2000.

<i>Ginkgo biloba</i> and <i>Panax ginseng</i> in history

The specific extract combination used by SFI Health: GK501 & G115

GK501 is the specific extract of Ginkgo biloba used in Gincosan. It is obtained from the dried leaves of the plant and is extracted and processed according to a similar principle as for G115. This ensures that the ‘standardised extract’ contains a consistent content of active ingredients; 24.5% ginkgoflavon glycosides and 6% terpenes (ginkgolides, bilobalide).

G115 is the specific extract of Panax ginseng used in Gincosan. Its first mention goes back to 1960, and it has over 35 years of research supporting it as an individual extract.9

The extract G115 is produced from the roots of Panax ginseng C.A. Meyer. This is where most of the important ingredients lie, including the active ingredient – the ‘ginsenosides’. It takes up to five years, and involves multiple steps for a Panax ginseng root to become G115, ensuring that there is an optimal concentration of the active therapeutic components. Thanks to a complex process, the G115 extract in Ginsana®, contains a consistent content of ginsenosides - 4% to be exact.

Because the GK501 and G115 extracts are specific and standardized, it is possible to investigate their effects on cognitive function in clinical trials. 

The beneficial effect of GK501 and G115 in Gincosan is based on numerous clinical trials in humans. Results from these clinical studies1-8 suggest that this patented combination can:

  • Support concentration
  • Improve mental alertness
  • Support healthy blood circulation
  • Maintain mental clarity
  • Enhance cognitive performance
The specific extract combination used by SFI Health: GK501 & G115

How GK501 & G115 works

The physiology of cognitive performance is a complex process, so the use of a combination of extracts that can act in multiple ways can be useful to support the processes involved. G115 and GK501 are combined in Gincosan to help improve cognitive function.

    Gincosan does this by helping to:

    • support and maintain healthy blood circulation including to the peripheral areas of the body
    • maintain brain function by acting as an antioxidant: helping to reduce free radical formation and damage to body cells
    How GK501 & G115 works

    GK105 and G115 in clinical trials

    The specific extracts used in Gincosan – known as GK105 and G115 – have been researched together over 20 years, in more than 7 clinical trials1-8, with a demonstrated good tolerability profile.

    Wesnes, KA, et al. 19971

    64 healthy adults over months

    Significant results

    vs. placebo for:

    • Cognitive function

    Randomised, double-blind, placebo controlled, parallel group study.

    Wesnes, KA, et al. 20002

    279 healthy adults over months

    Significant results

    vs. placebo for:

    • Cognitive function
    • Memory quality, speed of memory retrieval
    • Attention power and continuity

    Placebo controlled double-blind, parallel group multicentre clinical study. 

    Scholey AB, et al. 20023

    20 healthy young adults

    Significant results

    vs. placebo for:

    • Quality of memory, speed of attention, accuracy of memory task performance

    Gincosan dose of 320mg (2 capsules) enhanced cognitive performance with a sustained effect during the most challenging cognitive test. 

    Double-blind, placebo controlled studies. 

    This product may not be right for you. Read the warnings before purchase. Always read the label. Follow the directions for use. If symptoms persist, consult your health professional. 

    SFI Health Difference

    What makes Gincosan simply different?

    Medicines with naturally sourced active ingredients can vary considerably depending on the species of plant chosen, the way it’s grown, harvested, and produced. Therefore, it’s essential to ensure the active ingredient in your product is the same type, and in the same quantity, as the one tested in clinical trials.

    In Gincosan, we take care to use the same specific Ginkgo biloba and Panax ginseng extracts (combination of GK501 and G115) with the same specifications that have been researched in clinical studies to aid cognitive function and mental performance.1-6  That’s why you can be confident that Gincosan can offer the benefits demonstrated in the research.rocess with careful consideration and control at every stage of creation.


    GK501 & G115: A Summary

    Consistent quality

    Through our rigorous processes, quality controls and extensive testing we ensure that the G115 & GK501 extracts can offer desired health outcomes demonstrated by clinical trials.1-8

    >30 years of research and use

    Numerous clinical studies investigating the beneficial effect Panax ginseng & Ginkgo biloba in combination.1-8

    7+ Clinical studies

    Demonstrate the combined role of G115 & GK501 in supporting cognitive function and mental performance for both young and older adults.1-8

    Used worldwide

    To enhance mental alertness and cognitive performance.

    Available Resources

    The Importance of Plant Extracts

    The Importance of Plant Extracts

    Lifestyle insight

    Not all medicines with naturally sourced active ingredients are created equal – that's why SFI Health believes it's important to consider the specific herbal extract, not just herb names.

    Integrative Medicine & SFI Health
    1. Wesnes KA, et al. Psychopharmacol Bull 1997; 38 (4): 677-683.
    2. Wesnes KA, Ward T, McGinty A, Petrini O. Psychopharmacology (Berl). 2000; 152(4): 353-61.
    3. Scholey AB, Kennedy DO. Hum Psychopharmacol 2002; 17(1): 35-44.
    4. Kiesewetter, H, Jung, F & Wezel, E. Int J Clin Pharmacol Ther Toxicol. 1992; 30(3): 97-102.
    5. Kennedy, DO, Scholey, AB & Wesnes, KA, J Psychopharmacol. 2000; 151(4): 416-423.
    6. Kennedy DO, et al. Nutr Neurosci 2001;4(5):399-412.
    7. Kennedy DO, et al. Physiol Behav 2002;75(5):739-51.
    8. Reay, JL, Kennedy DO & Scholey AB, J Psychopharmacol. 2005;19(4): 357-65.
    9. Scaglione F et al., Evid Based Integrative Med 2005;2(4);195-206. 
    10. WHO Monographs on Selected Medicinal Plants, Volume 1, Geneva, World Health Organization, 154-167 (1999).
    11. Ginkgo folium: ESCOP Monographs: the Scientific Foundation for Herbal Medicinal Products, 2nd Edition, Exeter, ESCOP, 178- 210 (2003).

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